16982-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16982-21-1 name is Ethyl 2-amino-2-thioxoacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-bromo-1-phenylethan-1-one (0.50 g, 2.5 mmol)and ethyl 2-amino-2-thioxoacetate (0.50 g, 3.8 mmol) was dissolved in ethanol (10 mL). The solutionwas heated at reflux for 6 h and then cooled to room temperature. After being concentrated, the residuewas dissolved in ethyl acetate (20 mL); then the solution was washed with water and brine, dried overNa2SO4, and concentrated in vacuo. The residue was purified by chromatography on silica gel(petroleum ether:ethyl acetate = 20:1) to give 11 (0.43 g, 73.6%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-amino-2-thioxoacetate, and friends who are interested can also refer to it.
Reference:
Article; Wang, Xinran; Lin, Xuehua; Xu, Xuanqi; Li, Wei; Hao, Lijuan; Liu, Chunchi; Zhao, Dongmei; Cheng, Maosheng; Molecules; vol. 22; 11; (2017);,
Amide – Wikipedia,
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