Brief introduction of 563-83-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Isobutyramide, its application will become more common.

563-83-7,Some common heterocyclic compound, 563-83-7, name is Isobutyramide, molecular formula is C4H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 10 mL microwave vial, furopyrazine 8, 12a-c and 13 (0.3 mmol), amide (0.45 mmol, 1.5 equiv), Pd(OAc)2 (5 mol %), Xanthphos (7 mol %) and Cs2CO3 (3 equiv) were successively dissolved in THF (3 mL). The reaction tube was sealed and irradiated at a ceiling temperature of 140 C at 100 W maximum power for 30-45 min. After reaction, the mixture was cooled with an air flow for 2 min, extracted with ethylacetate (2¡Á50 mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was subjected to silica gel chromatography (from 5% to 20% EtOAC in heptane) to afford compounds 14a-j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Isobutyramide, its application will become more common.

Reference:
Article; Claerhout, Stijn; Sharma, Sweta; Skoeld, Christian; Cavaluzzo, Claudia; Sandstroem, Anja; Larhed, Mats; Thirumal, Meganathan; Parmar, Virinder S.; Van Der Eycken, Erik V.; Tetrahedron; vol. 68; 14; (2012); p. 3019 – 3029;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics