68524-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68524-30-1, name is 2-[(Diphenylmethyl)thio]acetamide, A new synthetic method of this compound is introduced below.
2-(Benzhydrylthio)acetamide obtained according to Example 4 (30 g-HPLC 97.9%) and acetic acid (120 ml) are loaded into a 1000 ml round-bottom flask. The mixture is heated to 40 C., slowly added with 35% hydrogen peroxide (11.7 g) and reacted at 40 C. for about 6 hours. The mixture is then cooled to 30 C., added with water (900 ml) and further cooled to 15 C. The product is filtered and washed with water. The wet product (49.4 g) thus obtained (HPLC: 95.73%, 0.083% (sulfone)) is dried at 50 C. under reduced pressure. Yield: 29.7 g. Crude modafinil is recrystallized from methanol (193 ml), by heating under reflux and cooling then to 15 C. The precipitate is filtered, washed with cold methanol and dried at 50 C. under reduced pressure. Yield: 23.4 g (HPLC: 99.9%, 0.01% (sulfone)).
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Reference:
Patent; PROCOS S.P.A.; US2004/106829; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics