71026-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71026-66-9 name is tert-Butyl (4-aminophenyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a three-necked flask equipped with a thermometer and a dropping funnelAzobenzene-4,4′-dicarboxylic acid dichloride (25.0 g,81.4 mmol) and triethylamine (19.8 g, 195.4 mmol) were added, and 150 mL of dichloromethane was added. The solution was kept at 5 CAnd the mixture was dissolved in methylene chloride (100 mL)4- (N-tert-butoxycarbonylamino) aniline(37.3 g,179.1 mmol) was added, and the mixture was heated to room temperature and stirred for 6 hours. The reaction solution was added to water (250 mL), washed with pure water(300 mL). The organic layer was washed three times. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain the same(Yield 42.9 g, yield 81%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jieenzhi Co., Ltd.; Jieenzhi Petrochemical Co., Ltd.; Teng Madaliang; Tian Cundianyang; Xiao Kouxiongerlang; Shan Neixiaohao; Jiu Tianlixiang; (145 pag.)CN104058993; (2017); B;,
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