90-16-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 90-16-4 as follows.
A solution of the alcohol from step 7 (0.050 g, 0.109 mmol), triphenylphosphine (0.057 g, 0.217 mmol) and benzo-1,2,3-triazin-4(3H)-one (0.034 g, 0.231 mmol) in THF (2.5 mL) was treated with diethyl azodicarboxylate (0.035mL, 0.222 mmol). The mixture was stirred at room temperature for 16 hrs., concentrated under reduced pressure and purified by MPLC (0-20% EtOAc-hexanes) to give the target compound (0.034g, 53%). TLC: Rf 0.16 (silica, 20% EtOAc-hexanes).
According to the analysis of related databases, 90-16-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bayer Corporation; EP923530; (2004); B1;,
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