34801-09-7, A common compound: 34801-09-7, name is N-(2-Aminophenyl)acetamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
General procedure: added 4-dimethylaminopyridine (DMAP) to compound 9 of anhydrous tetrahydrofuransolution, stirring at room temperature for 30 min. Then added N-(3-dimethylaminopropyl)-N’-ethylcarbodiimidehydrochloride (EDCI?HCl) was to the reaction mixture and continued stirring 0.5-1h. Phenylenediamine derivatives were added to the reaction mixture, continued stirringat room temperature under nitrogen until the disappearance of the startingmaterial 9 (TLC monitoring). Afterevaporation of the solvent, residue was diluted in CH2Cl2and washed with saturated NaHCO3, water and saturated NaCl. Theorganic layer was dried over Na2SO4, filtrated, and evaporatedthe solvent in vacuo. The resulting residue was purified by silica gelchromatography to yield the corresponding product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(2-Aminophenyl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Song, Jiao; Peng, Peng; Chang, Jun; Liu, Ming-Ming; Yu, Jian-Ming; Zhou, Lu; Sun, Xun; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2174 – 2178;,
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