In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 6292-59-7
44g (0.21 moles) of 4-tert-butyl-benzenesulfonamide, 72g (0.21 moles) of 4,6- dichloro-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidine and 0.7g of tetrabutylammonium bromide are added to a suspension of 35g (0.25 moles) of potassium carbonate in 720 ml of methyl isobutyl ketone (MIBK), kept in an inert atmosphere (nitrogen). Once the addition is complete, the suspension is heated to reflux, operating so as to azeotropically remove the water that forms during the reaction. The reaction is kept at reflux for 5 hours. Once the reaction is complete, the suspension is cooled to 5O0C and diluted with 0.2 litres of water. Hydrochloric acid 35percent is then added until obtaining a pH between 2.0 and 3.0. The suspension is cooled to 5¡ãC / 100C and the product is left to crystallise for 10 hours. The suspension is filtered and 120 g in wet form of the title compound are obtained equal to 100 g in dry form (0.19 moles) (yield 92percent; purity 99.6percent HPLC).
The synthetic route of 6292-59-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SIFAVITOR S.R.L.; BIFFI, Giancarlo; FELICIANI, Lazzaro; VISCARDI, Enrico; WO2010/103362; (2010); A2;,
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