Some common heterocyclic compound, 98-10-2, name is Benzenesulfonamide, molecular formula is C6H7NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 98-10-2
To a 500 ml flask was added 100 g of isopropanol,50g of benzene sulfonamide dissolved in the preparation of sodium hydroxide,Isopropanol-sodium alcohol solution (14g isopropyl alcohol dissolved in 26g isopropyl alcohol), water bath temperature, while opening the mechanical stirring,When the temperature to 50-55 C, the solid is completely dissolved, began dropping benzenesulfonyl chloride 62g, while dropping sodium hydroxide,Isopropanol-sodium alcohol solution (28g isopropyl alcohol sodium dissolved in 52g isopropyl alcohol), control system pH value of 8 to 10,Control the rate of dropping, dropping finished in 50-55 C for 2h, through the hydroxide anion exchange resin.The reaction solution was cooled to 10 C and centrifuged to obtain BBI sodium salt. The sodium salt is dissolved in hot water,Crystals were precipitated by lowering the temperature by SAPPS cation exchange resin, and the crystals were vacuum dried at 40-50 C,To obtain 84.7 g of solid bis-benzenesulfonimide. As shown in Fig. 7, the results of the HPLC detection showed: benzenesulfonamide: 0.02%;Benzenesulfonyl chloride: 0.02%; NaCl: 0.08%; BBI: 99.96%; Yield: 89%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98-10-2, its application will become more common.
Reference:
Patent; Hubei Kyrgyzstan and Chang Chemical Technology Co., Ltd; Xiao, Zhongxin; Feng, Qingcheng; Yang, Wei; Zhou, Shijun; Ming, Ruitao; Guo, Xinyue; Hu, Zhe; Huang, Kaiwei; (8 pag.)CN106187831; (2016); A;,
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