6292-59-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6292-59-7 name is 4-(tert-Butyl)benzenesulfonamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 3: Preparation of 4-tert-Butyl-N-[6-chloro5-(2-methoxyphenoxy) [2,2]- bipyrimidinyl-4-yl] -benzene sulfonamide compound of formula-4.p-t-butyl benzene sulphonamide (2.2g,0.0104mol) was taken in Dimethyl Sulphoxide and potassium carbonate was added (2.75g,0.0198mol) under inter atmosphere and stirred for 0.5h. 3.4g of 4,6- dichloro 5-(2-methoxyphenoxy) [2,2]-bipyrimidinyl compound (formula-3) 3.44g, 0.009mol was added and heated to 120¡ãC and maintained at the same temperature for 2h. The reaction mass was quenched in IN hydrochloric acid and stirred for 2h. Product precipitates out and was filtered and washed with water and dried under vacuum yielding 4.3g(96percent) of pale yellow crystalline solid 4,6- dichloro 5-(2-methoxyphenoxy) [2,2]- bipyrimidinyl compound of formula-3 having the X-ray diffraction pattern with peaks at 8.547, 9.867, 11.068, 11.97, 13.851, 14.726, 15.539, 17.213, 18.428, 20.463, 22.232, 22.704, 23.536, 23.937, 24.827, 26.291, 26.545, 27.294, 27.815, 28.223, 29.278, 30.022, 30.5, 31.447, 31.996, 32.454, 33.43, 33.644, 34.251, 34.89, 35.662, 36.393, 37.402, 38.523, 39.022, 40.238, 40.724, 41.35, 41.93, 43.732, 44.289, 45.24, 47.267, 47.978, 49.123, 49.438, 50.22, ¡À 0.2 degrees two theta values.This was optionally purified using acetonitrile under the reflux condition to give pure pale yellow to off white crystalline product for formula-4 having the XRD.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(tert-Butyl)benzenesulfonamide, and friends who are interested can also refer to it.
Reference:
Patent; BIOCON LIMITED; VENKATA, Srinivas, Pullela; KOTHAKONDA, Kiran, Kumar; RAJMAHENDRA, Shanmughasamy; CHANDRASEKARAN, Indrajit; KALIAPPAN, Mariappan; MAILAR, Rekha, Shivappa; WO2013/57545; (2013); A1;,
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