102-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102-93-2 name is 3-Phenylpropanamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
DCM (20 mL) was added to a flask containing Lawesson?s reagent (2.022 g, 5.00 mmol). 3-Phenylpropanamide (1 .492 g, 10.00 mmol) was dissolved in DCM (20 mL), added tothe suspension, and stirred at room temperature for 16 hours. The mixture was concentrated under reduced pressure and purified by column chromatography (DCM) to afford the title compound (1 .07 g 1H NMR (500 MHz, ODd3) O 7.30 (t, 2H), 7.24 – 7.21 (m, 3H), 3.12 (t, 2H), 2.95 (t, 2H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Phenylpropanamide, and friends who are interested can also refer to it.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BLUM, Francesca; CARR, James Lindsay; SHAH, Pritom; DEL MAR JIMENEZ QUESADA, Maria; FARRE GUTIERREZ, Irene; (213 pag.)WO2016/124938; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics