Some common heterocyclic compound, 116091-63-5, name is 2-Methoxy-5-(2-oxopropyl)benzenesulfonamide, molecular formula is C10H13NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 116091-63-5
Preparation of R,R-2-Methoxy-5-[2-(1-phenylethylamino)-propyl]benzenesulfonamide, hydrochloride (Formula IV) (3-sulfonamido-4-methoxyphenyl)-2-propanone obtained from Example 1 was added to methanol (300 ml) and activated Raney Ni (1.5 g) in a hydrogenation flask. R(+)-1-phenyl ethylamine (1 g) was added and hydrogen gas was applied at a pressure of 3.5 bar. Temperature was raised to 50 C. and pressure raised to 5.5. bar. The reaction mixture was cooled to room temperature and Raney Ni filtered through hyflo bed. The filtrate was concentrate under reduced pressure at 50 C. and toluene (10 ml) was added. The resultant solution was concentrated at 50-60 C. under reduced pressure to recover toluene completely and get a thick oil (3 g approx.) of the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 116091-63-5, its application will become more common.
Reference:
Patent; Ranbaxy Laboratory Limited; US6894188; (2005); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics