108468-00-4,Some common heterocyclic compound, 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, molecular formula is C13H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of 4-(Boc-aminomethyl)benzylamine (1) (1.0 mmol)and TEA (3.0 mmol) in anhydrous DCM (8 mL) was cooled with anice bath, then the corresponding sulfochloride (1.1 mmol, dissolvedin 2mL anhydrous DCM) was added dropwise. The reactionmixture was allowed to stir at 0 C for 1 h. After removing thecooling bath, the resulting mixture was stirred for 5 h at roomtemperature, then diluted with saturated aqueous NaHCO3 andextracted with DCM (10 mL) for three times. The combined organiclayer was sequentially washed with water and brine, dried withanhydrous Na2SO4, and concentrated in vacuo. The crude was purifiedby column chromatography with DCM/methanol (150:1, v/v)to yield the product as a white solid [5].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108468-00-4, its application will become more common.
Reference:
Article; Bai, Renren; Sun, Jian; Liang, Zhongxing; Yoon, Younghyoun; Salgado, Eric; Feng, Amber; Oum, Yoonhyeun; Xie, Yuanyuan; Shim, Hyunsuk; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 195 – 205;,
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