402-46-0, Adding some certain compound to certain chemical reactions, such as: 402-46-0, name is 4-Fluorobenzenesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 402-46-0.
General procedure: A general method for preparing (4,6-diaryl-tetrahydropyridin-3-yl) (aryl) methanone 4 includes the following steps: In a 10 mL sealed tube, aryl propynol (0.10 mmol),Solvent (0.50 1.00mL), acid (0.01 0.04mmol) and chalcone derivative (0.10 0.20mmol), heated and reacted under reflux conditions. The reaction was monitored by TLC. After the arylpropynol reaction was completed, Add amine compounds (0.10 0.20mmol) and carry out the reaction under reflux conditions. The reaction duration is about 9 ~ 11h, then add water to the reaction solution to quench the reaction, add ethyl acetate to extract the organic phase, and use the obtained organic phase for It was washed with saturated sodium chloride, dried over anhydrous sodium sulfate, and then concentrated on a rotary evaporator. The resulting concentrated solution was purified by column chromatography.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 402-46-0.
Reference:
Patent; Shanghai Institute of Technology; Yin Yan; Zhang Qinglin; Zhang Hua; Guo Huifeng; Pan Wanyong; Pei Keke; (18 pag.)CN110407739; (2019); A;,
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