7341-96-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7341-96-0 name is Propiolamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of imine (0.24 mmol), rhodium acetate (0.0024 mmol) and molecular sieves (300 mg) were mixed in a 10 mL one-Oil pump for nitrogen ventilation,A 1 mL syringe was added with 1 mL of re-evaporated CH2 Cl2 Prepared as a mixed solution A and stirred at room temperature for 10 minutes.The aryl diazonium compound (0.2 mmol) and the amide compound (0.2 mmol) were dissolved in 1 mL of re-evaporated CH2Cl2 Prepared into solution B. Solution B was added to the mixed solution A at 25 C with a syringe pump over 1 hour.Stirring 3 to 12 hours,The reaction mixture was purified by column chromatography to give pure product as shown in formula (j)Methyl (2S, 3S) -3- (2-formylmethyl) -3 – ((2-hydroxyphenyl) amino) -2-phenyl-2-propiolamide propionate,The yield was 40%Dr value equal to> 95: 5,HPLC purity was 97%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Propiolamide, and friends who are interested can also refer to it.
Reference:
Patent; East China Normal University; Liu Shunying; Lei Ruirui; Jia Kaili; Wu Yong; Liu Donglan; Dong Suzhen; Hu Wenhao; (42 pag.)CN106831474; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics