19982-07-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.
Add 38.9g of Compound A to a 500ml three-necked flask,The reaction bottle was placed in an ice-water bath, then 21.4ml of nitric acid was added, and then 270.4ml of sulfuric acid was slowly added, and the addition was completed in about 40 minutes. After the addition, the temperature was slowly raised to room temperature and the reaction was completed for 4h. Post-treatment: Pour the reaction solution into 1L of ice water, stir the reaction thoroughly after quenching, add dichloromethane (200ml ¡Á 5) for extraction, wash with saturated sodium chloride solution 300ml, dry with anhydrous magnesium sulfate, filter, the filtrate is reduced at 45 Autoclaved,The residue was recrystallized from ethyl acetate / n-hexane (V / V = 100ml / 100ml) at 0 C.After filtration, the filter cake was dried under vacuum (-0.09MPa) at 40 C for 3h to obtain 14.5g of product compound D. Yield: 34.8% and GC purity: 99.1%.
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Reference:
Patent; Chongqing Zhien Pharmaceutical Co., Ltd.; Chongqing Liujiang Pharmaceutical Technology Co., Ltd.; Mu Xiang; Zhang Wei; Han Juan; Li Yufang; Deng Xianglin; Xiang Yong; (9 pag.)CN110938006; (2020); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics