Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2675-89-0, name is 2-Chloro-N,N-dimethylacetamide, This compound has unique chemical properties. The synthetic route is as follows., 2675-89-0
To a stirred suspension of N-(4-(3-(5-tert-butylisoxazol-3- yl)ureido)phenyl)-5-(pyrrolidin-3-yloxy)picolinamide hydrochloride (150 mg, 0.30 mmol) in CH3CN (3 mL) was added TEA (126 muEpsilon, 0.90 mmol), KI (10 mg,0.060mmol), and 2-chloro-N,N-dimethylacetamide (21 muEpsilon , 0.30 mmol). The resulting mixture was heated at 85 C for 1 h. LC-MS indicated that the reaction was complete. The reaction mixture was evaporated under reduced pressure and the residue was purified by reverse phase HPLC to give N-(4-(3-(5-tert-butylisoxazol-3- yl)ureido)phenyl)-5 -( 1 -(2-(dimethylamino)-2-oxoethyl)pyrrolidin-3 – yloxy)picolinamide (110 mg, 67%). LC-MS (ESI) m/z 550 (M + H)+.
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Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; LIU, Gang; WO2011/150198; (2011); A1;,
Amide – Wikipedia,
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