749927-69-3, A common heterocyclic compound, 749927-69-3, name is 4-Bromo-2-fluoro-N-methylbenzamide, molecular formula is C8H7BrFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 14-bromo-N-methyl-2- 14-(2,2,2-trifluoroethyl)piperazin-1-ylj benzamide4-Bromo-2-fluoro-N-methylbenzamide (1.17 g, 5.04 mmol) was dissolved in dimethyl sulfoxide (8 mL). 1-(2,2,2-Trifluoroethyl)piperazine (1.69 g, 10.05 mmol) and K2C03 (1.5511.22 mmol) were added, and the reaction mixture was heated to 120 C for 17 hours. The reaction mixture was partition between water (100 mL) and ethyl acetate (3×100 mL). The combined organic layers were washed with brine (100 mL), dried over Mg504, filtered and concentrated. The residue was purified by silica gel chromatography (ethyl acetate, Rf=0.51) to give the titled compound (1.60 g, 83%). ?H NMR (300 MHz, DMSO-d6) 5 ppm2.75-2.80 (m, 7H), 2.92-2.95 (m, 4H), 3.24 (q. J=10.3 Hz, 2H), 7.25-7.28 (m, 2H), 7.48 (d, J=8.5 Hz, 1H), 8.58(q, J=4.4 Hz, 1H); MS(ESI+) m/z 380 & 382 (M+H).
The synthetic route of 749927-69-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE INC.; SCANIO, Marc; BUNNELLE, William; KOENIG, John Robert; DRIZIN, Irene; PLIUSHCHEV, Marina; COWART, Marlon; WO2015/112445; (2015); A1;,
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