109903-35-7, Adding a certain compound to certain chemical reactions, such as: 109903-35-7, name is 4-Amino-N-methylbenzenemethanesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109903-35-7.
To the [NITRO-LH-INDAZOLE-3-CARBOXYLIC] acid (1 equiv. ) of Example 63A in DMF (0.3 M) was added EDC (1.2 equiv. ), HOBT (1.2 equiv. ), NMM (1.2 equiv. ) and then 4- [METHYLSULPHAMOYLMETHYL-PHENYLAMINE] (1.3 equiv. ) at room temperature. The reaction was heated to [70 C] for 2 hours and then stirred at room temperature for 48 hours. Water was added to the reaction mixture and the precipitated product was filtered. The solid was washed with water, then a small volume [OF MEOH,] and then dried in a vacuum oven to leave a yellow solid.
According to the analysis of related databases, 109903-35-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTEX TECHNOLOGY LIMITED; WO2004/14864; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics