Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-46-0, name is 4-Fluorobenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., 402-46-0
Ar under the protection, A solution of 1-methyl-4 – ((3-methoxyphenyl) amino) -7-chloro-1H-indole- (1001 ^, 0 ¡¤ 30mmo 1) Dissolved in dry DCM, Followed by addition of HATU (172 mg, 0.45 mmo 1) DMAP (18 mg, 0.15 mmo 1) And TEA (92 mg, 0.90 mmol), After stirring, 4-fluorobenzenesulfonamide (80 mg, 0.45 mmol) was added and incubated overnight at room temperature, After the reaction, the solvent was distilled off, Followed by dilute hydrochloric acid, washed with water, combined EA layer, column separation of light yellow green solid (75mg, 51.4%)
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Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Shen Zhufang; Bie Jianbo; Mu Yongzhao; Chen Hualong; Liu Lvnan; Zhou Jie; Li Caina; Cao Ran; Huan Yi; Sun Shujuan; (258 pag.)CN107098846; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics