1103234-56-5, Adding a certain compound to certain chemical reactions, such as: 1103234-56-5, name is 2,6-Difluoro-3-(propylsulfonamido)benzoic acid, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1103234-56-5.
EXAMPLE 4 Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (1) A suspension of sulfonamide acid (9) (1.2 eq.) in CH2Cl2 was treated at room temperature with cat. amount of DMF (0.11 eq.). Within 30 min a solution of oxalylchloride (1.30 eq.) in CH2Cl2 was added and the reaction mixture was stirred for 2 h, whereby the corresponding acid chloride was formed. A suspension of aluminium chloride (AlCl3, 4 eq.) in CH2Cl2 was treated at 0 C. with a solution of Cl-phenyl azaindole (8) in CH2Cl2. To the reaction mixture was subsequently added at room temperature the freshly prepared (above described) acid chloride. Stirring at room temperature for 3 h, aqueous work-up and crystallization from THF/heptane provided the title compound (1) as off-white powder in 85% yield. MS (Turbo Spry): 509 (48%), 507 (M+NH4+, 100%), 492 (40%), 490 (M+H+, 84%).
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Reference:
Patent; Brumsted, Corey James; Moorlag, Hendrik; Radinov, Roumen Nikolaev; Ren, Yi; Waldmeier, Pius; US2012/22258; (2012); A1;,
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