57561-39-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57561-39-4 name is tert-Butyl (2-hydroxyethyl)(methyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of tert-butyl (2-hydroxyethyl)(methyl)carbamate (1.0 g, 5.71 mmol) and triethylamine (1.15 g, 11.41 mmol) in dichloromethane (20 mL) was added dropwise methanesulfonyl chloride (975.86 mg, 8.56 mmol). The mixture was stirred at 0 C. for 1 hour. The resulting solution was washed with water and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum to afford 2-[tert-butoxycarbonyl(methyl)amino]ethyl methanesulfonate (1.29 g, 5.08 mmol) as a colorless oil. LCMS (ESI) [M+H]+=254
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (2-hydroxyethyl)(methyl)carbamate, and friends who are interested can also refer to it.
Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
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