360-64-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 360-64-5, name is 2-(Trifluoromethyl)benzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[Step 2] Ethyl 5-({[2-(Trifluoromethyl)phenyl]carbonyl}amino)-2,3-dihydro-1-benzofuran-7-carboxylate 1,4-dioxane (20 ml) was added to ethyl 5-bromo-2,3-dihydro-1-benzofuran-7-carboxylate (600 mg), 2-(trifluoromethyl)benzamide (501 mg), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) (96 mg), cesium carbonate (1.01g) and 140 tris(dibenzylideneacetone)dipalladium (114 mg). After degassing, the mixture was stirred at 100C under argon atmosphere for 24 hours. The reaction mixture was filtered off on celite, the solvent was removed under reduced pressure. The resultant residue was purified on silica gel column chromatography to obtain the titled compound (220 mg) as slightly yellow powder.
The synthetic route of 360-64-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; OTSU, Hironori; EP2746265; (2015); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics