Application of 62009-47-6

Adding some certain compound to certain chemical reactions, such as: 62009-47-6, name is 2-Aminomalonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62009-47-6. 62009-47-6

Diethylaminomalonate Aminomalondiamide 2-Carbamido-3-hydroxypynazine To an aqueous solution of diethylaminomalonate (hydrochloride form) was added sodium hydrogenocarbonate (pH> 7). After extraction, the organic phase was evaporated under reduced pressure and treated with an ammoniacal solution of methanol at 80C overnight to give aminomalondiamide quantitatively. This compound was used for next step without purification and dissolved in water. To that solution was added glyoxal sodium bisulfite hemihydrate, this reaction mixture was stirred at 90C for 3h, and then made basic with 58% NH4OH. Then, 30% H2O2 was added dropwise with rapid stirring to the cold solution (0C) [J. Med. Chem. 1983, 26, 283-86, J. Heterocyclic Chem. 1979, 16, 193]. The reaction mixture was allowed to warm at room temperature and the desired 2-hydroxy-3- carboxamidopyrazine precipitated. The solid was collected (63% yield) and part of it recrystallized.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Aminomalonamide.

Reference:
Patent; IDENIX (CAYMAN) LIMITED; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WO2007/144686; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics