In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121492-06-6 as follows. 121492-06-6
DMF (20 ml), QHL 014 (4.42 g, 9.2 mmol), N-BOC-N-methyl ethylenediamine (2.00 g, 12.5 mmol), HATU (4.20 g, 11 mmol) was added in a 50 ml single-necked flask. After stirring for 5 minutes, DIPEA (5 ml, 27.6 mmol) was added dropwise. Stir at room temperature until QHL014 is completely reacted. DMF was evaporated under reduced pressure, and the crude product was dissolved in ethyl acetate and washed with water. The organic phase was dried and purified by silica gel column chromatography (dichloromethane: methanol = 50:1 to 20:1) to obtain light yellow solid QHL 015 (4.81 g, yield 80%).
According to the analysis of related databases, 121492-06-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd.; LIU, Yuan; LIU, Cheng; WANG, Haiyang; (43 pag.)EP3572420; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics