The chemical industry reduces the impact on the environment during synthesis 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, I believe this compound will play a more active role in future production and life. 112101-81-2
10 g of (-)- (R)-5- (2- (2- (2-ethoxyphenoxy) ethylamino)-1-propyl)-2-methoxybenzene sulphonamide hydrochloride (TH) from Example 2 is recrystallised from mixtures of methanol and ethanol. Analysis : Methanol HPLC-composition Quantity of Yield HPLC-composition to ethanol of the starting raw solvent of the product* ratio material* used 100 : 0 TH 86. 1 % 120 mi 7. 77 g TH 95. 84 % impurity (2) 1. 53 % (77. 7 %) impurity (2) 0. 09 % impurity (3) 2. 84 % impurity (3) 0. 0 % impurity (4) 1. 79 % impurity (4) 0. 24 % impurity (5) 0. 98 % impurity (5) 0. 05 % impurity (6) 6. 17 % impurity (6) 3. 73 % 90 : 10 TH 86. 1 % 75 g TH 95. 5% impurity (2) 1. 53 % (77, 5%) impurity (2) 0. 12 % impurity (3) 2. 84 % impurity (3) 0. 0 % impurity (4) 1. 79 % impurity (4) 0. 31 % impurity (5) 0. 98 % impurity (5) 0. 08 % impurity (6) 6. 17 % impurity (6) 3. 94 % 70 : 30 TH 86. 1 % 210 ml 7, 78g TH 95. 9 % impurity (2) 1. 53 % (77. 8 %) impurity (2) 0. 12 % impurity (3) 2. 84 % impurity (3) 0. 0 % impurity (4) 0. impurity 0. 31 % impurity (5) 1. 79 % impurity (5) 0. 08 % impurity (6) 6. 17 % impurity (6) 3. 49 % 50 : 50 TH 86. 1 % 340 ml 7. 41 g TH 99. 27% impurity (2) 1. 53 % (74. 1 %) impurity (2) 0. 15 % impurity (3) 2. 84 % impurity (3) 0. 0 % impurity (4) 0. 98 % impurity (4) 0. 32 % impurity 1. 79 % impurity (5) 0. 08 % impurity (6) 6. 17 % impurity (6) 0. 0 % 30 : 70 TH 86. 1 % 500 ml 7. 55 g TH 99. 28 % impurity (2) 1. 53 % (75. 5 %) impurity (2) 0. 17 % impurity (3) 1. 79 % impurity (3) 0. 0 % impurity (4) 0. 98 % impurity (4) 0. 32 % impurity (5) 1. 79 % impurity (5) 0. 10 % impurity (6) 6. 17 % impurity (6) 0. 0 % * impurity (2) = 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide impurity (3) = 2-(2-ethoxyphenoxy) ethylbromide impurity (4) = N-(2-(2-ethoxyphenoxy) ethyl)-5-(2-(2-(2-ethoxyphenoxy) ethyl) amino)-1-propyl)-2-methoxybenzenesulphonamide impurity (5) = 5-(2-(bis-(2-(2-ethoxyphenoxy) ethyl) amino)-1-propyl)-2-methoxybenzenesulphonamide impurity (6) = 1,2-bis (2-ethoxyphenoxy) ethane (6)
The chemical industry reduces the impact on the environment during synthesis 112101-81-2. I believe this compound will play a more active role in future production and life.
Reference:
Patent; LEK PHARMACEUTICALS D.D.; WO2005/63702; (2005); A1;,
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