2675-89-0, Name is 2-Chloro-N,N-dimethylacetamide, 2675-89-0, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Preparation 2: (2184) To a solution of (2185) 6-(3-isopropyl-5-(piperidin-4-yl)-lH-indol-2-yl)-8-methoxy-[l,2,4]triazolo[l,5-a]pyridin e, HC1 (30.6 g, 71.8 mmol) in a DMF (700 mL) solvent mixture were added (2186) 2-chloro-N,N-dimethylacetamide (9.62 mL, 93 mmol) and TEA (50.1 mL, 359 mmol) at room temperature. The reaction mixture was stirred at room temperature for 12 h. The starting material was converted to product. Next, water (2 L) was added to the above solution, the upper layer and the lower layer were extracted with ethyl acetate. The combination of the organic layers was washed with brine, dried and concentrated to give a solid, which was purified by recrystallization from ethanol to afford (2187) 2-(4-(3-isopropyl-2-(8-methoxy-[l,2,4]triazolo[l,5-a]pyridin-6-yl)-lH-indol-5-yl)piperid in-l-yl)-N,N-dimethylacetamide (28.3 g, 59.3 mmol, 83 % yield). LCMS MH+: 475.2. HPLC Ret. Time 0.66 min. Method G. C: 68.28%, H: 7.19%, N: 17.63%.
Statistics shows that 2-Chloro-N,N-dimethylacetamide is playing an increasingly important role. we look forward to future research findings about 2675-89-0.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DYCKMAN, Alaric J.; DODD, Dharmpal S.; HAQUE, Tasir Shamsul; LOMBARDO, Louis J.; MACOR, John E.; MUSSARI, Christopher P.; PASUNOORI, Laxman; RATNA KUMAR, Sreekantha; SHERWOOD, Trevor C.; POSY, Shoshana L.; SISTLA, Ramesh Kumar; HEGDE, Subramaya; RAMACHANDRA, Anupama; (425 pag.)WO2018/5586; (2018); A1;,
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