112101-81-2, A common compound: 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
7.0 g of recrystallised (-)-(R)-5-(2-(2-(2-ethoxyphenoxy) ethylamino)-1-propyl)-2- methoxybenzenesulphonamide hydrochloride (TH) from Example 3 is recrystallised from mixtures of methanol and ethanol. Analysis : Methanol to HPLC-composition of Quantity Yield HPLC-composition of ethanol the starting raw of solvent the product* ratio material* used 100 : 0 TH 95. 84 % 90 ml 5. 44 g TH 97. 77 % impurity (2) 0. 09 % (77. 7%) impurity (2) 0. 0 % impurity (3) 0. 0 % impurity (3) 0. 0 % impurity (4) 0. 24 % impurity (4) 0. 04 % impurity (5) 0. 05 % impurity (5) 0. 0 % impurity (6) 3. 73 % impurity (_) 2. 19 % 90 : 10 TH 95. 5 % 110 ml 5. 64 g TH 97. 53 % impurity (2) 0. 12 % (80. 6%) impurity (2) 0. 12 % impurity (3) 0. 0 % impurity (3) 0. 0 % impurity (4) 0. 31 % impurity (4) 0. 06 % impurity (2 0. 08 % impurity (5) 0. 00 % impurity (6) 3. 94 % impurity (6) 2. 41 % 70 : 30 TH 95. 9 % 160 ml 5. 70 g TH 99. 89 % impurity (2) 0. 12 % (81. 4%) impurity (2) 0. 0 % impurity (3) 0. 0 % impurity (3) 0. 0 % impurity 0. 31 % impurity (4) 0. 05 % impurity (5) 0. 08 % impurity (5) 0. 0 % impurity (6) 3. 49 % impurity (6) 0. 0 % 50 : 50 TH 99. 27 % 230 ml 5. 95g TH 99. 85 % impurity (2) 0. 15 % (85. 0%) impurity (2) 0. 0 % impurity (3) 0. 0 % impurity (3) 0. 0 % impurity (4) 0. 32 % impurity (4) 0. 06 % impurity (5) 0. 08 % impurity (5) 0. 0 % impurity (6) 0. 0% impurity 0. 0% 30 : 70 TH 99. 28 % 340ml 5. 98 g TH 99. 81 % impurity (2) 0. 17 % (85. 4%) impurity (2) 0. 02 % impurity (3) 0. 0 % impurity (3) 0. 0 % impurity (4) 0. 32 % impurity (4) 0. 08 % impurity (5) 0. 10 % impurity (5) 0. 0 % impurity (6) 0. 0 % impurity (6) 0. 0 % * impurity (2) = 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide impurity (3) = 2-(2-ethoxyphenoxy) ethylbromide impurity N- (2- (2-ethoxyphenoxy) ethyl)-5- (2- (2- (2-ethoxyphenoxy) ethyl) amino)-1-propyl)-2-methoxybenzenesulphonamide impurity (5) = 5-(2-(bis-(2-(2-ethoxyphenoxy) ethyl) amino)-1-propyl)-2-methoxybenzenesulphonamide impurity (6) = 1,2-bis (2-ethoxyphenoxy) ethane (6)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LEK PHARMACEUTICALS D.D.; WO2005/63702; (2005); A1;,
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