7462-74-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7462-74-0, name is 2-Bromo-2-methylpropanamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 5 (R)-2-(3-N,N-Dibenzylamino-3,4-dihydro-2H-1-benzopyran-5-yloxy)-2-methylpropanamide (R)-3-N,N-Dibenzylamino-5-hydroxy-3,4-dihydro-2H-1-benzopyran (35.4 g, 100 mmol) was dissolved in anhydrous 1,4-dioxane (350 mL) under nitrogen. A dispersion of sodium hydride (60-65% in oil, 5.33 g, 130 mmol) was added in portions. The mixture was stirred for 2 h at room temperature. 2-Bromo-2-methylpropanamide (17.9 g, 110 mmol; described in Coutts, I. G. C.; Southcott, M. R. J. Chem. Soc. Perkin Trans. 1 1990, 767-771) was added to the dark greenish solution and was heated at reflux with stirring for 3 h. After cooling, a small amount of water was added, the solution was decanted, and the solvent was removed in vacuo. The residue was partitioned between ethyl acetate (350 mL) and a saturated NaHCO3 solution (50 mL). The organic layer was dried (MgSO4), and the solvent was removed in vacuo to give a brownish residue which was chromatographed on a short column of silica gel (eluent: hexane/ethyl acetate; 55:45) affording 27.6 g (64% yield) of the title compound as a white solid: mp 132-134 C.; [alpha]22D-92 (c 1.0, chloroform); EIMS (70 eV) m/z (relative intensity) 430 (6, M+).
The synthetic route of 7462-74-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Astrazeneca AB; US6479497; (2002); B1;,
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