A common heterocyclic compound, 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, molecular formula is C11H20N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 141449-85-6.
The 5 – chloro – 1, 6 – naphthyridine (0.93 g, 5 . 65 mmol), hexahydro-pyrrolo [3, 4 – c] pyrrole -2 (1 H) – formic acid tert-butyl ester (1.00 g, 4 . 71 mmol), three (dibenzylidene acetone) two palladium (0.43 g, 0 . 47 mmol), 2 – dicyclohexyl phosphorus – 2, 4, 6 – triisopropyl biphenyl (0.46 g, 0 . 94 mmol), sodium tertiary butyl alcohol (1.40 g, 14.1 mmol) and toluene (20 ml) are added to the 100 ml single-port in the bottle, under the protection of nitrogen, reaction temperature to 120 C reaction 36 hours. Stopping the reaction, the reaction solution is distilled under reduced pressure to remove the solvent after purification by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=1/1) to obtain the title compound (light yellow liquid, 1.15 g, 71.7%).
The synthetic route of tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhang Yingjun; Xue Yaping; Lao Jinhua; Nie Biao; Xu Juan; (35 pag.)CN107759620; (2018); A;,
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