Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 226260-01-1, name is 3-Fluoro-N-methoxy-N-methylbenzamide, A new synthetic method of this compound is introduced below., 226260-01-1
2. 35 ml of a 1 molar solution of vinylmagnesium bromide in THF is added dropwise under nitrogen to a solution, held at 0 C., of 5.80 g (31.6 mmol) of 3-fluoro-N-methoxy-N-methylbenzamide in 70 ml of THF.The reaction mixture is stirred at room temperature for 40 minutes, then saturated ammonium chloride solution is added, and the mixture is stirred at room temperature for a further 10 minutes. tert-Butyl methyl ether is added to the reaction mixture. The organic phase is separated off, washed with sodium hydrogencarbonate solution and water and dried in vacuo: 1-(3-fluorophenyl)-3-(methoxymethylamino)propan-1-one as yellow oil; ESI 212.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Dorsch, Dieter; Schadt, Oliver; Blaukat, Andree; US2008/249095; (2008); A1;,
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