Some common heterocyclic compound, 96-30-0, name is 2-Chloro-N-methylacetamide, molecular formula is C3H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 96-30-0
X-2 100 mg (0.288 mmol), 2-chloro-N-methylacetamide 37 mg (0.344 mmol), Cs2CO3281 mg (0.862 mmol) and 10 mL DMF were added to a 100 mL single-necked flask.The reaction was carried out at 50 degrees overnight, and the reaction was complete by TLC. The reaction solution was poured into 50 mL of water.EA was extracted with 30 mL*3, and the organic phase was combined with a sand column to obtain 80 mg of a white solid.Yield 66.4%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96-30-0, its application will become more common.
Reference:
Patent; China Pharmaceutical University; Lu Tao; Zhang Li; Zhao Jingyun; Zhang Beichen; Chen Yadong; (19 pag.)CN109897054; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics