The chemical industry reduces the impact on the environment during synthesis 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, I believe this compound will play a more active role in future production and life. 112257-19-9
To a solution of 2 (465mg, 2.66mmol) in CH2Cl2 (20mL) was added 8 (500mg, 2.66mmol) and sodium triacetoxyborohydride (1.13g, 5.32mmol) at 0¡ãC under argon and then stirred at room temperature for 12h. The reaction solution was quenched with saturated NH4Cl (20mL) and extracted with CH2Cl2 (30mL ¡Á 3), and the combined organic layers dried with Na2SO4. The residue was purified by column chromatography on silica gel using EtOAc/petroleum ether (1/2, V/V) as elunt to give 10 as colorless oil (750mg, 81percent); 1H NMR (400MHz, DMSO) delta 6.49 (d, J = 3.2Hz, 1H, Ar-H), 6.35 (d, J = 3.2Hz, 1H, Ar-H), 3.52 (s, 2H, CH2), 3.29-3.20 (m, 2H, CH2), 2.76 (d, J = 9.8Hz, 3H, CH3), 2.42 (t, J = 6.7Hz, 2H, CH2), 2.18 (s, 3H, CH3), 1.45 (s, 9H, (CH3)3); HRMS (ESI) m/z [M+H]+ Calcd for C14H24BrN2O3+: 347.0970. Found: 347.0974.
The chemical industry reduces the impact on the environment during synthesis 112257-19-9. I believe this compound will play a more active role in future production and life.
Reference:
Article; Yang, Hao; Ouyang, Yifan; Ma, Hao; Cong, Hui; Zhuang, Chunlin; Lok, Wun-Taai; Wang, Zhe; Zhu, Xuanli; Sun, Yutong; Hong, Wei; Wang, Hao; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4635 – 4642;,
Amide – Wikipedia,
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